African Health Sciences
Makerere University Medical School
Vol. 18, No. 4, 2018, pp. 950-957
Bioline Code: hs18116
Full paper language: English
Document type: Study
Document available free of charge
African Health Sciences, Vol. 18, No. 4, 2018, pp. 950-957
© Copyright 2018 - Onodugo et al.
Prevalence of autonomic dysfunction among pre-dialysis chronic kidney disease patients in a tertiary hospital, South East Nigeria|
Onodugo, Obinna; Arodiwe, Ejikeme; Okoye, Julius; Ezeala, Birinus; Onodugo, Nkiru; Ulasi, Ifeoma & Ijoma, Chinwuba
Background: Autonomic dysfunction (AD) has been recognized as an important contributor to the poor outcome in chronic
kidney disease (CKD) patients. Several studies have reported abnormalities in heart rate variability (HRV) among these patients.
Objectives: To determine the prevalence of Autonomic Dysfunction (AD) in pre-dialysis Chronic Kidney Disease (CKD) patients in a tertiary hospital in South East Nigeria.
Methods: A cross sectional study of eighty chronic kidney disease patients attending the renal unit out-patient in the University of Nigeria Teaching Hospital (UNTH) Enugu was carried out. Forty subjects, drawn randomly, who had no kidney disease
served as control. Autonomic function was assessed with non – invasive cardiovascular tests including, measurement of resting
tachycardia, orthostatic hypotension, heart rate response (HRR) to standing test, heart rate response to Vasalva manoeuvre and
heart rate response to respiration.
Results: With the battery of 5 tests used to assess AD, the frequency of autonomic dysfunction in pre-dialysis chronic kidney
disease patients was 51.3% compared to 7.5% in the control group. Heart rate response to standing was the most sensitive test
to detect AD in this group of subjects.
Conclusion: AD is a common problem among pre-dialysis CKD patients in Nigeria.
Prevalence; autonomic dysfunction; pre-dialysis