African Health Sciences
Makerere University Medical School
Vol. 18, No. 4, 2018, pp. 958-964
Bioline Code: hs18117
Full paper language: English
Document type: Study
Document available free of charge
African Health Sciences, Vol. 18, No. 4, 2018, pp. 958-964
© Copyright 2018 - El-Masry et al.
Breast cancer resistance protein (BCRP) gene expression in a cohort of adult Egyptian patients with acute myeloid leukemia|
El-Masry, Manal W; Gouda, Heba M; Shaheen, Iman A; Edesa, Wael; Hassan, Naglaa M & Ramzy, Rehab
Background: Acute myeloid leukemia (AML), an aggressive clonal disease, is genetically heterozygous. The prognostic role
of expression of Breast Cancer Resistance Protein (BCRP) gene, which behaves as a multidrug transporter, in adult AML is
Objective: The objective is to assess the level of mRNA expression of BCRP gene in newly diagnosed cytogenetically normal
adult Egyptian AML patients; and to clarify its potential influence and association between therapeutic responsiveness and disease free survival.
Methods: The BCRP gene expression was evaluated by quantifying its mRNA using real time RT-PCR in fifty newly diagnosed
cytogenetically normal adult AML patients and 20 healthy normal controls. The expression was evaluated in relation to clinical
and prognostic factors, response to treatment and the survival rate.
Results: BCRP mRNA was over expressed in adult AML patients compared to controls. This study showed a positive statistical
correlation between BCRP gene expression and the percent of CD34 expression. Statistical analysis did not reveal any association between BCRP expression level and chemotherapeutic responsiveness or disease free survival rate.
Conclusion: The significance of BCRP gene expression and its function in AML is very complicated, therefore more standardized clinical studies are needed.
BCRP; adult AML; gene expression; prognosis; Egypt.