African Health Sciences
Makerere University Medical School
Vol. 18, No. 4, 2018, pp. 979-987
Bioline Code: hs18121
Full paper language: English
Document type: Study
Document available free of charge
African Health Sciences, Vol. 18, No. 4, 2018, pp. 979-987
© Copyright 2018 - Obi et al.
Red blood cell alloimmunization in multi-transfused patients with chronic kidney disease in Port Harcourt, South-South Nigeria|
Obi, Esther Ifeoma; Pughikumo, Crosdale Ogho & Oko-jaja, Richard Ishmael
Background: Serological safety is an integral part of overall safety for blood banks.
Objectives: The aim of the study was to determine the prevalence and specificities of red blood cell alloimmunization in
multi-transfused patients with chronic kidney disease (CKD).
Methods: A cross-sectional case-control study carried out at the University of Port Harcourt Teaching Hospital in which 186
patients with CKD were enrolled consecutively, 124 had received multiple transfusions (more than one unit of blood in one
month, or at least 10 units within 3 months), while 62 had never been transfused. Antibody screen test was performed by the
gel agglutination technique. RBC antibody identification was performed on the sera of those that tested positive to antibody
Results: Out of the 124 multi-transfused patients (total of 789 transfusions), 4 (3.2%) were alloimmunised. The alloimmunised
patients received a higher mean number of 17.5 ± 12 blood units, compared to 6 ± 6 units by the non-alloimmunised multi-transfused patient (p= <0.001). Six clinically significant alloantibodies were identified with all of the alloimmunised patients forming
more than one antibody. Anti-E was detected in all alloimmunised patients.
Conclusion: The prevalence of RBC alloimmunisation in multi-transfused CKD patients was 3.2% with anti-E being the most
frequently identified antibody.
Red blood cell alloimmunization; chronic kidney disease; Port Harcourt; South-south Nigeria.