African Health Sciences
Makerere University Medical School
Vol. 18, No. 4, 2018, pp. 1283-1291
Bioline Code: hs18135
Full paper language: English
Document type: Study
Document available free of charge
African Health Sciences, Vol. 18, No. 4, 2018, pp. 1283-1291
© Copyright 2018 - Adegboye et al.
Dose related effects of oral clonidine pre-medication on bupivacaine spinal anaesthesia|
Adegboye, MB; Kolawole, IK & Bolaji, BO
Introduction: The duration of action of sub-arachnoid block is short, and one of the ways to overcome this is the use of oral
Methods: 108 patients of ASA I and II, aged 18 to 65 years undergoing lower abdominal surgeries under spinal anaesthesia
were randomized into three groups.. Control group A (n=36) no oral clonidine pre-medication, Group B (n=36) and group C
(n=36) received 100 μg and 200 μg of oral clonidine pre-medication respectively, 1hr before spinal anaesthesia. Haemodynamic
parameters were recorded. Sensory block, degree of motor blockage, and sedation were assessed.
Results: Clonidine prolonged the mean duration of motor block by 189.98±26.93 min (100μg) and 191.89±28.13 min (200μg)
compared to 117.92±25.13 min in the control group p<0.05. The mean duration of analgesia was 188.19±35 min (100μg)
and194±24.58 min (200μg) in the clonidine groups compared to 115.89±26.66 min in control group p<0.05. All the patients
were awake in the control group while 71.43% and 100% were drowsy in groups B and C respectively.
Conclusion: Oral clonidine produces better clinical effects on the onset and duration of Bupivacaine spinal anaesthesia.
Spinal anaesthesia; pre-medication; clonidine; duration of action; duration of action