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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 19, No. 1, 2019, pp. 1594-1601
Bioline Code: hs19033
Full paper language: English
Document type: Research Article
Document available free of charge

African Health Sciences, Vol. 19, No. 1, 2019, pp. 1594-1601

 en A randomized controlled clinical trial evaluating the effect of Trigonella foenum-graecum check for this species in other resources (fenugreek) versus glibenclamide in patients with diabetes
Najdi, Rania A; Hagras, Magda M; Kamel, Fatemah O & Magadm, Rania M


Background: Herbal medicines long have been used in the management of diabetes mellitus (DM).
Objective: This study was conducted to ascertain if fenugreek compared with glibenclamide had any impacts on controlling blood glucose in patients with uncontrolled type II DM on conventional therapy.
Methods: A total of 12 patients with uncontrolled DM and on metformin were recruited and divided into two groups. Patients in group 1 received 2 g fenugreek per day, whereas those in group 2 received glibenclamide 5 mg once daily. The impacts of fenugreek on the glycemic control and lipid profile were measured before initiation of the regimen and then after 12 weeks.
Results: Only 9 of the 12 study participants completed the study. Fenugreek at 2 g/day caused an insignificant drop in fasting blood glucose (P = 0.63), but the fasting insulin level increased significantly (P = 0.04). The ratio of high- to low-density lipoprotein was significantly decreased from before to after treatment (P = 0.006). Fenugreek did not cause any notable adverse impacts on hepatic and renal functions throughout the study.
Conclusion: Fenugreek could be used as adjuvant therapy to anti-diabetic drugs to control blood glucose, and further studies are needed.

Cite as: Najdi RA, Hagras MM, Kamel FO, RM M. A randomized controlled clinical trial evaluating the effect of Trigonella foenum-graecum (fenugreek) versus glibenclamide in patients with diabetes. Afri Health Sci. 2019;19(1). 1594-1601.

Trigonella foenum-graecum (fenugreek); glibenclamide; diabetes

© Copyright 2019 - Najdi et al.

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