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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 19, No. 1, 2019, pp. 1607-1616
Bioline Code: hs19035
Full paper language: English
Document type: Study
Document available free of charge

African Health Sciences, Vol. 19, No. 1, 2019, pp. 1607-1616

 en Utility of albumin to creatinine ratio in screening for microalbuminuria among newly diagnosed diabetic patients in Uganda: a cross sectional study
Muddu, Martin; Mutebi, Edrisa; Ssinabulya, Isaac; Kizito, Samuel; Mulindwa, Frank & Kiiza, Charles Mondo

Abstract

Background: The aim of this study was to determine the prevalence and factors associated with microalbuminuria among newly diagnosed diabetic patients in Mulago National Referral Hospital, Uganda.
Methods: In this cross-sectional study conducted between June 2014 and January 2015, we collected information on patients' socio-demographics, biophysical profile, blood pressure, biochemical testing and echocardiographic findings using a pre-tested questionnaire. Bivariate and multivariate logistic regression analyses were used to investigate the association of several factors with microalbuminuria.
Results: Of the 175 patients recruited, males were 90(51.4%) and the mean age was 46±15 years. Majority of patients had type 2 DM 140 (80.0%) and the rest had type 1 DM 35 (20.0%). Mean glycated hemoglobin (HbA1C) was 13.9±5.3%. Mean duration of diabetes was 2 months. Prevalence of microalbuminuria was 47.4 % (95% CI: 40.0%-54.9%) overall. Pregnancy was associated with microalbuminuria (OR7.74[95%CI.1.01-76.47] P=0.050) while mild and moderate physical activity at work were inversely associated with microalbuminuria respectively (OR0.08[95%CI0.01-0.95] P=0.046) and (OR0.07[95%CI0.01-0.77] P=0.030).
Conclusion: Prevalence of microalbuminuria was high in this group. Physical activity at work may be protective against microalbuminuria and this calls for longitudinal studies. Early detection and management of microalbuminuria in diabetics may slow progression to overt diabetic nephropathy (DN).

DOI: https://dx.doi.org/10.4314/ahs.v19i1.36
Cite as: Muddu M, Mutebi E, Ssinabulya I, Kizito S, Mulindwa F, CM K. Utility of albumin to creatinine ratio in screening for microalbuminuria among newly diagnosed diabetic patients in Uganda: a cross sectional study. Afri Health Sci. 2019;19(1). 1607-1616. https://dx.doi. org/10.4314/ahs.v19i1.36

Keywords
Albumin; creatinine; microalbuminuria; diabetic patients; Uganda

 
© Copyright 2019 - Muddu et al.

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