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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 19, No. 1, 2019, pp. 1647-1656
Bioline Code: hs19039
Full paper language: English
Document type: Study
Document available free of charge

African Health Sciences, Vol. 19, No. 1, 2019, pp. 1647-1656

 en Anthracycline induced cardiotoxicity in adult cancer patients: a prospective cohort study from a specialized oncology treatment centre in Uganda
Kibudde, Solomon; Mondo, Charles Kiiza; Kibirige, Davis; Walusansa, Victoria & Orem, Jackson

Abstract

Purpose: To determine the cumulative incidence of anthracycline induced cardiotoxicity (AIC), its predictors, and associated electrocardiographic and echocardiographic manifestations in adult cancer patients at Uganda Cancer Institute (UCI).
Methods: We enrolled 160 participants between June 2013 and April 2014 and followed them up for a median of 146 days. Data on clinical, electrocardiographic and echocardiographic findings was obtained at baseline, and at completion of chemotherapy. The Pearson chi square test was used to identify the predictors associated with cardiotoxicity.
Results: Of the 64 patients who were accessible for follow-up electrocardiography (ECG) and echocardiography (ECHO), fourteen participants developed cardiotoxicity hence a cumulative incidence rate of 21.9% with 95% CI 13.5%- 33.43%. The predictors of AIC were female gender (p=0.025), LVEF (p=0.014) and LVFS (P=0.019). Anthracycline therapy was associated with shortening of the QRS duration (84.3±7.9 Vs 82.1±11.8 ms, p=0.005), prolongation of the QTc interval (411.9±30.7 Vs 447.2±39.4 ms, p=<0.001) and reduction in the LVEF (66.4±7.7 Vs 63.9±8.4%, p=0.026) and LVFS (36.9±6.2 Vs 35.1±6.6%, p=0.03).
Conclusion: The cumulative incidence of AIC in this study cohort was high. Our findings emphasize the need for early monitoring for AIC.

DOI: https://dx.doi.org/10.4314/ahs.v19i1.40
Cite as: Kibudde S, Mondo CK, Kibirige D, Walusansa V, J O. Anthracycline induced cardiotoxicity in adult cancer patients: a prospective cohort study from a specialized oncology treatment centre in Uganda. Afri Health Sci. 2019;19(1). 1647-1656. https://dx.doi.org/10.4314/ahs. v19i1.40

Keywords
Anthracycline induced cardiotoxicity; cancer patients; Uganda

 
© Copyright 2019 - Kibudde et al.

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