A significant proportion of newborns in the developing countries are born with congenital anomalies.
This study investigated congenital infections due to Rubella virus, Toxoplasma gondii
, Treponema pallidum
among presumed normal neonates from full term pregnant women in Mwanza, Tanzania.
Sera from mothers were tested for Treponema pallidum
and Toxoplasma gondii
infection while newborns from mothers
with acute infections were tested for T. pallidum
and T. gondii
, and all newborns were tested for Rubella IgM antibodies.
A total of 13/300 (4.3 %) mothers had T. pallidum
antibodies with 3 of them having acute infection. Two (0.7 %) of
the newborns from mothers with acute infection were confirmed to have congenital syphilis. Regarding toxoplasmosis, 92/300
(30.7 %) mothers were IgG seropositive and 7 had borderline positivity, with only 1/99 (1%) being IgM seropositive who delivered IgM seronegative neonate. Only 1/300 (0.3 %) newborn had rubella IgM antibodies indicating congenital rubella infection.
Based on these results, it is estimated that in Mwanza city in every 100,000 live births about 300 and 600 newborns
have congenital rubella and syphilis infections, respectively. Rubella virus and T. pallidum
are likely to be among common causes
of congenital infections in developing countries.
Cite as: Mirambo MM, Mshana SE, Groβ U. Rubella virus, Toxoplasma gondii and Treponema pallidum congenital infections among full term
delivered women in an urban area of Tanzania: a call for improved antenatal care. Afri Health Sci.2019;19(2): 1858-1865. https://dx.doi.org/10.4314/ahs.v19i2.8