Microbial infection of the genital tract or semen is one of the leading causes of male infertility. Consequently,
there is a need to seek alternative products from natural sources.
The antibacterial, phytochemical and cytogenotoxicological assessments of the aqueous extract of Cymbopogon citratus
leaf were evaluated.
The antibacterial potential of the extract was done via agar-well diffusion and microdilution techniques. The phytochemical analysis was done via standard protocols.The cytogenotoxicity of the extract were analyzed using the Allium cepa
All test organisms were found to be sensitive to the extract except Pseudomonas. aeruginosa
where no measurable zone of
inhibition could be ascertained at all concentrations assessed.The highest mean inhibition diameter of 21.33±1.20mm against S. sapophyticus
was recorded and a concentration-dependent susceptibility noticed. The phytochemical results revealed the presence
of saponins, flavonoid, glycoside, steroids, terpenoid and alkaloids. The Alliumcepa
root showed reduced mitotic indices following aconcentration-dependent increase in the extract.It can be said that the aqueous extract of C. citratus
had inhibitory activities
against the tested pathogenic organisms with relative anti-tumour potential.
This study indicated, C. citratus
could be a potential source for antibacterial compounds for the possible treatment
of male reproductive related infections.
Cite as: Erhabor JO, Erhabor RC, ldu M. In vitro antibacterial and cytogenotoxicological properties of the aqueous extract of Cymbopogon citratusStapf (DC) leaf. Afri Health Sci.2019;19(2): 2056-2067. https://dx.doi.org/10.4314/ahs.v19i2.29