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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 19, No. 2, 2019, pp. 2156-2163
Bioline Code: hs19100
Full paper language: English
Document type: Research Article
Document available free of charge

African Health Sciences, Vol. 19, No. 2, 2019, pp. 2156-2163

 en Polysaccharides obtained from mycelia of Cordyceps militaris check for this species in other resources attenuated doxorubicin-induced cytotoxic effects in chemotherapy
Lin, Ruo-Kai; Choong, Chen-Yen; Hsu, Wei-Hsuan; Tai, Chen-Jei & Tai, Cheng-Jeng

Abstract


Objectives: Fungus Cordyceps militaris has been used as a herbal tonic in traditional Chinese medicine, which could be surface liquid-cultured for mycelia production. To evaluate the potential of polysaccharides obtained from mycelia of Cordyceps militaris (PS-MCM) for attenuation of side-effects of chemotherapy.
Methods: Doxorubicin was used to induce cytotoxicity in THP-1 monocytes and EL-4 T cells, and the effects of PS-MCM on cell viability and cytokine production were detected on doxorubicin-treated THP-1 and EL-4 cells.
Results: PS-MCM reduced doxorubicin-induced cell death and promoted cell proliferation in THP-1 and EL-4 cells. Moreover, PS-MCM elevated the level of cytokines associated with immune-modulation of THP-1 and EL-4 cells.
Conclusion: These findings indicate that PS-MCM has potential for development as a functional food to counteract side effects of chemotherapy.

DOI: https://dx.doi.org/10.4314/ahs.v19i2.40
Cite as: Lin R-K, Choong C-Y, Hsu W-H, Tai C-J, Tai C-J. Polysaccharides obtained from mycelia of Cordyceps militaris attenuated doxorubicin-induced cytotoxic effects in chemotherapy. Afri Health Sci.2019;19(2): 2156-2163. https://dx.doi.org/10.4314/ahs.v19i2.40

Keywords
Cordyceps militaris; traditional Chinese medicine; doxorubicin; chemotherapy; immunotherapy

 
© Copyright 2019 - Lin et al.

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