Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder with strong genetic components. The reported
association of vitamin D receptor (VDR) gene polymorphisms varies among ethnic groups.
The present study was conducted to determine association of vitamin D receptor gene Bsm
I (rs1544410 A>G) polymorphism with type 2 diabetes mellitus in Pakistani population.
Blood samples were collected from 150 T2DM patients and 100 non-diabetic engaged by convenient sampling
method. After collection of demographic data, assessment of fasting glucose (FG), vitamin D, HbA1c, renal function tests, liver
function tests and lipid profile was done. Candidate gene polymorphism was analyzed by DNA amplification with polymerase
chain reaction and endonuclease digestion.
Biochemical parameters were significantly different among case and control groups. Associations of Bsm
I genotype with T2DM, related complications and biochemical variables were not significant.
The current study did not provide evidence for the association of VDR gene Bsm
I polymorphism with T2DM in
Cite as: Fatma H, Abdul SN. Association of vitamin D receptor gene BsmI polymorphism with type 2 diabetes mellitus in Pakistani population.Afri Health Sci.2019;19(2): 2164-2171. https://dx.doi.org/10.4314/ahs.v19i2.41