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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 19, No. 3, 2019, pp. 2468-2475
Bioline Code: hs19137
Full paper language: English
Document type: Review Article
Document available free of charge

African Health Sciences, Vol. 19, No. 3, 2019, pp. 2468-2475

 en Review of immunohistochemical typing of endometrial carcinoma at the Lagos University Teaching Hospital
Dawodu, Olayemi Olubunmi; Okunade, Kehinde Sharafadeen; Daramola, Adetola & Banjo, Adekunbiola Aina Fehintola

Abstract

Background: Categorization of endometrial carcinomas as type I and II provides useful insights into their different risk factors, pathogenesis and biologic behaviours.
Aim: To determine the immunohistochemical classifications of endometrial carcinomas in Nigerian women.
Design: A retrospective review of histopathologic slides of cases of endometrial carcinomas seen at the Lagos University Teaching Hospital (LUTH) over a 5-year period. The slides were reviewed, and the diagnoses made according to the WHO nomenclature. The classification of endometrial carcinomas into Type I and II was made by immunohistochemistry using antibodies to ER, PR, p53 and Ki-67.
Results: Eight cases of endometrial adenocarcinoma were reported accounting for 53.3% of all endometrial malignancies. Of these, only 1 case showed the classic type I immunophenotype while type II staining pattern was seen in 4 cases. The remaining 3 cases had equivocal immunophenotypes: one was p53+ but showed ER+, PR+ and high Ki-67 index; the second was p53-, ER+, PR+ but had a high Ki-67 expression; while the last was p53-, but ER-, PR- and had high Ki-67 expression.
Conclusion: Endometrial carcinomas in Nigerian women are more likely to be type II carcinomas. A reasonable proportion of the cases were equivocal thus requiring further categorization with molecular studies.

Keywords
Endometrial carcinomas; immunohistochemistry; LUTH; Nigerian.

 
© Copyright 2019 - Dawodu et al.

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