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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 19, No. 3, 2019, pp. 2526-2536
Bioline Code: hs19143
Full paper language: English
Document type: Research Article
Document available free of charge

African Health Sciences, Vol. 19, No. 3, 2019, pp. 2526-2536

 en Anxiolytic and anti-depressant effects of hydroalcoholic extract from Erythrina variegata check for this species in other resources and its possible mechanism of action
Chu, Hong-Biao; Tan, Yue-De; Li, Yun-Jing; Cheng, Bin-Bin; Rao, Bao-Qi & Zhou, Ling-Shan

Abstract

Background: Erythrina variegata has been widely used as a traditional medicine.
Objective: The study was designed to evaluate the anxiolytic and anti-depressant effects of an extract from Erythrina variegata.
Methods: The extract was evaluated for anxiolytic and anti-depressant action using the elevated plus maze, light/dark box, open field, forced swimming and tail suspension tests in mice. The mechanism of action was further elucidated using high-performance liquid chromatography with fluorescence detection methods to assay the levels of five neurotransmitters in brain.
Results: The extract exhibited significant increase in the percentage of the open arms entries and the time spent in the open arms in the elevated plus maze test. The results of the light/dark box test revealed a significant increase in the amount of time spent in the light chamber. Extract- treated mice also produced significant increase in the number of crossings and rearings in the open field test.In the forced swimming and tail suspension tests, the extract was able to promote significant decrease in the immobility time. In addition, the extract significantly altered the levels of five neurotransmitters in the brain tissue.
Conclusion: These findings suggest that Erythrina variegata presents potential anxiolytic and anti-depressant activity, and the mechanism may be related to the alteration of neurotransmitter levels.

Keywords
Anxiolytic; anti-depressant; Erythrina variegata; elevated plus maze; forced swimming; neurotransmitters.

 
© Copyright 2019 - Chu et al.

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