African Health Sciences
Makerere University Medical School
Vol. 20, No. 2, 2020, pp. 806-814
Bioline Code: hs20050
Full paper language: English
Document type: Study
Document available free of charge
African Health Sciences, Vol. 20, No. 2, 2020, pp. 806-814
© Copyright 2020 - Oham A et al.
Subcutaneous ketamine prolongs the analgesic effect of local infiltration of plain Bupivacaine in children undergoing inguinal herniotomy|
Oham, Alex; Ekwere, Ifeoma & Tobi, Kingsley
Background: Inguinal herniotomy is one of the commonest paediatric surgical procedures at the University of Benin
Teaching Hospital. Incisional infiltration with plain bupivacaine has been used to provide postoperative analgesia for this
procedure but with a short duration of action, 4- 6hours.
Aims/Objectives: The aim of this study therefore was to evaluate the efficacy of subcutaneous ketamine on post-operative
analgesia in children undergoing unilateral inguinal herniotomy
Methods: Forty-six (46) ASA I or II patients aged three to seven years scheduled for unilateral inguinal herniotomy were
recruited. The patients were randomized to receive surgical wound site infiltration with plain bupivacaine plus subcutaneous
injection of ketamine for group I or surgical wound site infiltration plain bupivacaine plus 2ml of saline subcutaneously for
group II at the end of surgery. Data obtained were analyzed using SPSS version 20. Continuous data were compared using
student t-test while categorical data were compared using Chi-square or Fisher's exact test. P- value <0.05 was considered
Results: In group, I, the mean time to first analgesic request was 667.7 minutes (11.12hours) and in group II, it was 371.3minutes (6.2 hours) with p<0.001. The pain scores were better and more favourable in group I from the 8th hour and above of
the assessment period. The mean post-operative analgesic consumption in 24 hours was less in group I (19.35±5.4mg) than
in group II (27.32±5.8 mg) with p-value <0.001.
Conclusion: The study showed that subcutaneous ketamine prolonged the analgesic effect of plain bupivacaine surgical
wound site infiltration in children undergoing unilateral inguinal herniotomy.
Subcutaneous ketamine; inguinal herniotomy; children; postoperative analgesia.