Background and Objective: Chemotherapy is one of the important medical option for the cancer therapy, but still new
combination of therapeutic treatment methods are needed to achieve efficient anti tumor activity. In this work,
Pueraria lobata
leaf extract was utilized as a bio reductant for the fabrication of the Gold nanoparticles (Au-NPs) by an ecological approach
without using any harmful chemical. This work also evaluates whether the combined effect of chemotherapy along with
Au-NPs and Ultrasound (US) is effective over the tumors or not.
Materials and methods: About 10 mL of plant extract was added to 1mM of HAuCl4 solution (20.0 mL) and pH was
maintained at 12 and allowed for stirring for half an hour. The change in solution color from yellow to purple signified the
Au-NPs formation.
Results: XRD results and TEM images confirmed the formation of crystalline Au-NPs with sizes ranging from 23-30 nm.
Further, biological studies revealed that the combination of Au-NPs and US along with chemotherapy improved the impact
of anti-cancer drug.
Conclusion: In conclusion,
Pueraria lobata leaf extract mediated synthesis of Au-NPs by an eco-friendly approach was
reported in this work. The plant biomolecules of the extract were involved in the reduction and capping of the Au-NPs
formed. The major conclusion is that addition of Au-NPs with chemotherapy and ultrasound has shown more effective
anti-tumor activity.
