African Health Sciences
Makerere University Medical School
Vol. 20, No. 2, 2020, pp. 841-848
Bioline Code: hs20054
Full paper language: English
Document type: Study
Document available free of charge
African Health Sciences, Vol. 20, No. 2, 2020, pp. 841-848
© Copyright 2020 - Ahmed AM et al.
Frequency and severity of ketoacidosis at diagnosis among childhood type 1 diabetes in Khartoum state, Sudan|
Ahmed, Ahmed M; Khabour, Omar F; Ahmed, Samia M; Alebaid, Ibrahim A & Ibrahim, Amna M
Background: Diabetic ketoacidosis (DKA) is a potentially life threatening acute complication of Type I diabetes mellitus
(T1DM). This study aimed to determine the frequency and clinical characteristics of pediatric DKA at diagnosis of new-onset
T1DM in Khartoum during 2000- 2017 period.
Methods: The study was retrospective and involved review of medical files of children (<15 years) with T1DM in the city hospitals and diabetes centers.
Results: The overall frequency of DKA among T1DM children at onset of disease diagnosis was 17.6% (173/982). The episodes of DKA increased from 26% in first 6- year period (2000-2005) to 46.3% in the last 6-year period (2011-2012; p<0.001).
No significant difference in the frequency of DKA was observed according to gender (p=0.9) and age (p=0.24). Compared to
other age groups, the severity of DKA (pH<7.1) was higher in pre-school children (p<0.01). Approximately, 5% of patients
were complicated with cerebral edema with a mortality rate of 1.7%.
Conclusion: The DKA frequency at diagnosis of childhood T1DM in Khartoum was lower than previous reports. In addition,
the severity of DKA was high among pre-school age children with a relatively high mortality rate when compared to the global
Ketoacidosis; mortality; onset; DKA; T1DM; Sudan; Khartoum.