Effect of levetiracetam drug on antioxidant and liver enzymes in epileptic patients: case-control study|
Mahdavi, Atena; Naeini, Amirmansour Alavi; Najafi, Mohammadreza; Maracy, Mohammadreza & Ghazvini, Mohammadreza Aghaye
Background: There is a limited amount of data regarding levetiracetam (LEV), an antiepileptic drug.
Objective: This study was conducted to assess the effect of LEV on antioxidant status and liver enzymes.
Method: In this case-control study, 33 epileptic patients under treatment with LEV for at least 6 months were compared
with 35 healthy subjects. We measured serum total antioxidant capacity (TAC), salivary superoxide dismutase (SOD), alanine
aminoteransferase (ALT), and aspartate aminoteransferase (AST) levels in both groups. Dietary intakes were collected using
a Food Frequency Questionnaire (FFQ).
Result: The level of TAC in the healthy subjects was significantly higher than it was in the patients (P=0.02), but the mean
of ALT (P=0.02) and AST (P=0.03) was significantly higher in the patients in comparison with the controls. Mean salivary
SOD showed no difference between the two groups. In the patients, the duration of drug use was inversely correlated with
serum TAC (p=0.04) and had a direct correlation with ALT (p=0.01) and AST (p=0.03.).
Conclusion: The results of our study indicated that LEV increased liver enzymes Also, treatment with this drug did not
improve oxidative stress, but this could be due to the different in the dietary antioxidant intake. Routine screening of the liver
and antioxidant enzymes in patients with chronic use of LEV is recommended.
levetiracetam; antioxidant; liver enzymes; epilepsy