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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 20, No. 3, 2020, pp. 1045
Bioline Code: hs20080
Full paper language: English
Document type: Study
Document available free of charge

African Health Sciences, Vol. 20, No. 3, 2020, pp. 1045

 en Prevalence and antibiotic susceptibility pattern of bacteriuria among HIV-seropositive patients attending the Bamenda Regional Hospital, Cameroon
Samje, Moses; Yongwa, Onesimus; Enekegbe, Alice Mbi & Njoya, Simon


Background: HIV causes a decrease in CD4+ lymphocyte cells count, exposing the individual to infections (urinary tract infections). This study was carried out to determine the prevalence of bacteriuria and antimicrobial susceptibility pattern of bacteria isolates among HIV patients.
Methods: Clean catch mid-stream urine samples were collected from 135 HIV- seropositive patients, cultured on Cystein lactose electrolyte deficient (CLED) agar and incubated at 370C for 24 hours. The modified Kirby-Bauer’s disc diffusion method was used to assess susceptibility to antimicrobial agents.
Results: The prevalence of bacteriuria was 67.4% (91/135). Staphylococcus aureus check for this species in other resources was the most predominant (42.9%) isolate, followed by Escherichia. coli check for this species in other resources (24.2%), then Coagulase negative Staphylococci (10.9%). The highest proportion of bacteria was isolated from patients having a CD4+ T-cell count of less than 300 cells/mm3 (39.6%). There was an association between the level of CD4+cell count and bacterial urinary tract infection (P= 0.001). Most sensitive drugs were gentamycin, vancomycin and amoxicillin-clavulanic acid while the drug with the greatest resistance was sulphamethoxazole-trimethoprim, with Enterococcus check for this species in other resources and Proteus check for this species in other resources showing 100% resistance to this drug.
Conclusion: Bacteriuria and resistance to commonly used antibiotics is prevalent among HIV/AIDS patients attending the Bamenda Regional Hospital. Therapy based on antimicrobial susceptibility test is encouraged.

Bacteriuria; HIV-seropositive patients; susceptibility; CD4+ T-cell.

© Copyright 2020 - Samje M et al.

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