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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 20, No. 3, 2020, pp. 1109-1117
Bioline Code: hs20084
Full paper language: English
Document type: Study
Document available free of charge

African Health Sciences, Vol. 20, No. 3, 2020, pp. 1109-1117

 en Vancomycin intermediate resistant Staphylococcus aureus check for this species in other resources in the nasal cavity of asymptomatic individuals: a potential public health challenge
Adeoye-Isijola, Morenike; Olajuyigbe, Olufunmiso; Adebola, Kehinde; Coopoosamy, Roger & Afolayan, Anthony


Background: The potential of transmitting multidrug resistant Staphylococcus aureus from asymptomatic individuals to healthy individuals could constitute a great challenge to antimicrobial therapy.
Methods: The antibiograms of the S. aureus from asymptomatic individuals were determined by disk diffusion and agar dilution assay techniques with different antibiotics and vancomycin.
Results: Of the 152 S. aureus isolated, (59)38.8% isolates were multi-drug resistant strains. Streptomycin was the most effective and inhibited (135)88.82% of the isolates while ceftazidime inhibited (24)15.8% of the isolates. While (82)54.0% of the isolates inhibited by cefuroxime had resistant colonies within their inhibition zones (Rc) and ofloxacin inhibited (100)65.8% of the isolates without having resistant colonies within the inhibition zones, ceftazidime inhibited (7)4.6% of the isolates with resistant colonies within the inhibition zones. Subjecting the isolates to vancomycin showed that (27)17.8% were resistant to 2 μg/ml, (43)28.3% were resistant to 4 μg/ml and (27)17.8% of the isolates were simultaneously resistant to both concentrations of vancomycin. Although (100)65.8% of the isolates had MARindex ≥0.2, (52)34.2% of the isolates had MARindex ≤ 0.2 and (65)428% of the isolates were considered multidrug resistant strains.
Conclusion: The isolation of multi-drug and vancomycin intermediate resistant strains of S. aureus in high percentage, in this study, presents a great threat to clinicians and general populace. The vancomycin intermediate resistant S. aureus (VISA) in asymptomatic individuals could be a critical concern to the therapeutic dilemma to be added to the presence of multi-drug resistance. A more sustainable therapy must be in place to prevent its dissemination or the outbreak of its infection.

Antibacterial activity; multidrug resistance; VRSA; VISA; vancomycin

© Copyright 2020 - Adeoye-Isijola M et al.

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