Dengue fever (DF) is a globally significant infection which causes a range of severe and non-severe clinical
manifestations. It is transmitted by mosquitoes of the Aedes
genus (primarily Aedes aegypti
, but also Aedes albopictus
In this letter, a possible DF epidemic on Thasos Island in Greece, which is described in the Book of
Epidemics I of the Corpus Hippocraticum, is presented and analyzed. To my knowledge, it is the first report of
DF in the history of medicine.