The relationship between epicardial fat thickness and high-grade varicocele|
Sincer, Isa; Erdal, Emrah; Gucuk, Adnan; Bostancı, Emre & Gunes, Yilmaz
Background: Varicocele is abnormal dilation of testis veins. The precise mechanism of varicocele is not fully understood
despite some hypothesis were suggested in the literature. Disequilibrium between constrictor and dilatator mechanism of
the veins have been shown to cause varicocele. High-grade varicoceles have been also linked to endothelial dysfunction and
Objectives: We hypothesized that epicardial fat thickness (EFT), flow-mediated dilatation (FMD) and aortic stiffness (AS)
could be associated with varicocele. In the present study, we aimed to compare vascular parameters such as FMD, EFT and
AS in healthy subjects and high-grade varicocele patients.
Methods: The study population consisted of 35 men with high-grade varicocele and 32 age- and sex-matched control
subjects younger than 45 years old. This is a cross-sectional study conducted at Bolu Abant Izzet Baysal University Hospital
between May to October 2018.
Results: EFT, aortic diastolic diameters (AoDD) and EFT/BMI ratio were significantly higher in control group than in patients
with high-grade (p=0.012, p=0.044, p=0.026, respectively). EFT and EFT /BMI ratio were significantly and inversely
correlated with presence of varicocele (r=-0.422, p=0.009; r=-0.38, p=0.026, respectively).
Conclusion: The present study suggests that high-grade varicocele may be associated with decreased echocardiographic
EFT but not with aortic stiffness and FMD.
High-grade varicocele; epicardial fat thickness; flow-mediated dilatation; aortic stiffness.