African Health Sciences
Makerere University Medical School
Vol. 20, No. 4, 2020, pp. 1610-1616
Bioline Code: hs20117
Full paper language: English
Document type: Study
Document available free of charge
African Health Sciences, Vol. 20, No. 4, 2020, pp. 1610-1616
© Copyright 2020 - Zhang Y et al.
Association between osteoporosis and hepatitis B cirrhosis: a case-control study|
Zhang, Yijin; Gao, Xuesong; Liu, Ting; Gao, Ping; Li, Hongjie; Liu, Nan; Gao, Lili; Wan, Gang; Zhang, Yaonan & Duan, Xuefei
Background and aims: Hepatitis B virus (HBV)-related cirrhosis is associated with decreased bone mineral density (BMD);
however, the mechanism is yet unknown. To assess the incidence of osteoporosis in patients with HBV-associated cirrhosis
and relevant mechanisms.
Methods: A total of 80 hospitalized patients with HBV-associated cirrhosis and 80 healthy controls were enrolled. The
levels of serum osteocalcin, total procollagen type 1 amino-terminal propeptide, β-C-terminal telopeptide of type I collagen
(β-CTX), and 25-hydroxy vitamin D3 (25(OH)D3) was evaluated in the cirrhosis group.
Results: The BMDs of the lumbar spine (P<0.001) and hip joints (P=0.015) in the cirrhosis group were significantly lower
than those in the controls. The incidence of osteoporosis in the cirrhosis group was significantly higher than that in the control
group (P<0.001). Compared to the patients of the Child-Pugh grade A and B, the BMD of lumbar spine and 25(OH)D3
was significantly decreased in patients of grade C, while β-CTX was elevated. Patients in the cirrhosis group faced a higher
risk of osteoporosis as compared to the controls(P<0.001).
Conclusions: Enhanced bone resorption accounted for increased risk of osteoporosis in severe cirrhosis. Thus, HBV-associated
cirrhosis was a risk factor for osteoporosis.
Liver cirrhosis; bone density; osteoporosis; osteopenia; hepatitis B; chronic.