Association between APOC3 polymorphisms and non-alcoholic fatty liver disease risk: a meta-analysis|
Wang, Jun; Ye, Chuncui & Fei, Sujuan
Background and Aim: The apolipoprotein C3 (APOC3) polymorphism has been reported to predispose to non-alcoholic
fatty liver disease (NAFLD). However, the results remain inconclusive. This meta-analysis aimed to provide insights into the
association between APOC3 polymorphisms and NAFLD risk.
Methods: Studies with terms “NALFD” and “APOC3” were retrieved from PubMed, Web of Science, CNKI and Wanfang
databases up to August 1, 2019. Pooled odds ratio (OR) and 95% confidence interval (95% CI) for the association of
APOC3 polymorphisms and NAFLD risk were calculated using fixed and random-effects models.
Results: A total of twelve studies from eleven articles were included. Of them, eight studies (1750 cases and 2181 controls)
reported the strong association of variant rs2854116 with NAFLD and six studies (1523 cases and 1568 controls) found the
association of rs2854117 polymorphism with NAFLD. Overall, a statistically significant association between rs2854116 polymorphism
of APOC3 gene and NAFLD risk was found only under dominant model. However, association of rs2854117
polymorphism with NAFLD risk was not detected under all four genetic models. In sub-group analysis of NAFLD subjects
based on country, no association among them in China was detected. Besides, four studies analyze the association between
the two polymorphisms and clinical characteristics in all subjects or NAFLD patients, and we also failed detect any association
between the wild carriers and variant carriers.
Conclusion: The meta-analyses suggests that the rs2854116 polymorphism but not rs2854117 polymorphism in APOC3
gene might be a risk factor for NAFLD among Asians. That is, individuals with CT+CC genotype have higher risk of developing
NAFLD. However, studies with sufficient sample size are needed for the further validation.
Apolipoprotein C3; polymorphism; non-alcoholic fatty liver disease; meta-analysis.