African Health Sciences
Makerere University Medical School
Vol. 20, No. 4, 2020, pp. 1880-1886
Bioline Code: hs20151
Full paper language: English
Document type: Research Article
Document available free of charge
African Health Sciences, Vol. 20, No. 4, 2020, pp. 1880-1886
© Copyright 2020 - Gokosmanoglu F et al.
The relationship between Vitamin D deficiency and polycystic ovary syndrome|
Gokosmanoglu, Feyzi; Onmez, Attila & Ergenç, Hasan
Background: Vitamin D deficiency is frequently seen in patients with polycystic ovary syndrome (PCOS) and has been
shown to exhibit multiple effects on the disease process. The purpose of this study was to investigate the role of vitamin D
deficiency in complex PCOS pathophysiological pathways.
Methods: Two hundred sixty-seven patients with PCOS were divided into two groups Group 1 with 25(OH)D3 deficiency,
and Group 2 with normal 25(OH)D3. Biochemical and hormonal parameters (androgen hormones, gonadotropins, and
thyroid function tests) were compared between the two groups.
Results: Eighty-six percent of the patients (n=231) were in Group 1 and 14% (n=36) in Group 2. Statistically significantly
higher concentrations of serum testosterone, dehydroepiandrosterone-sulfate and LH were determined in Group
1 (p<0.05). 25(OH)D3 concentrations were negatively correlated with body mass index (r=−0.459), serum testosterone (r
=−0.374) and dehydroepiandrosterone-sulfate levels (r=−0.418); (all; p< 0.05).
Conclusion: The study findings show that low 25(OH)D3 levels are associated with high androgen levels in women with
PCOS. Vitamin D deficiency should be considered as an additional risk factor in the development of PCOS. We think that
providing vitamin D supplementation for women from identified deficiency areas can reduce the risk of PCOS development.
Polycystic ovarian syndrome; vitamin D deficiency; androgen hormones; testosterone