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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 20, No. 4, 2020, pp. 1887-1894
Bioline Code: hs20152
Full paper language: English
Document type: Review Article
Document available free of charge

African Health Sciences, Vol. 20, No. 4, 2020, pp. 1887-1894

 en Micro RNAs and the biological clock: a target for diseases associated with a loss of circadian regulation
Ma, Qianwen; Mo, Genlin & Tan, Yong


Background: Circadian clocks are self-sustaining oscillators that coordinate behavior and physiology over a 24 hour period, achieving time-dependent homeostasis with the external environment. The molecular clocks driving circadian rhythmic changes are based on intertwined transcriptional/translational feedback loops that combine with a range of environmental and metabolic stimuli to generate daily internal programing. Understanding how biological rhythms are generated throughout the body and the reasons for their dysregulation can provide avenues for temporally directed therapeutics.
Summary: In recent years, microRNAs have been shown to play important roles in the regulation of the circadian clock, particularly in Drosophila check for this species in other resources , but also in some small animal and human studies. This review will summarize our current understanding of the role of miRNAs during clock regulation, with a particular focus on the control of clock regulated gene expression.

MicroRNAs; biological clock; circadian rhythm.

© Copyright 2020 - Ma Q et al.

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