African Health Sciences
Makerere University Medical School
Vol. 21, No. 1, 2021, pp. 1-7
Bioline Code: hs21001
Full paper language: English
Document type: Research Article
Document available free of charge
African Health Sciences, Vol. 21, No. 1, 2021, pp. 1-7
© Copyright 2021 - Mburugu P et al.
Antiretroviral therapy outcomes among adolescents and young adults in a Tertiary hospital in Kenya|
Mburugu, Patrick; Muiruri, Peter; Opiyo, Nelly; Simba, Justus; Adunda, Jane; Kawira, Rosemary & Gachuno, Onesmus
Background: Limited data is available on the treatment outcomes of HIV infected adolescents and young adults (AYA) in
sub-Saharan Africa. HIV-infected adolescents and young adults (AYA) are at high risk of developing antiretroviral treatment
Objective: To determine the clinical, immunological and virologic outcomes of AYA at a tertiary hospital in Kenya.
Methodology: A longitudinal study was conducted among AYA age 10-24 years attending Kenyatta National Hospital
comprehensive care center. Clinical data was abstracted from electronic medical records for study participants with at least
6 months of follow-up using a structured data abstraction sheet.
Results: A total of 250 AYA age 10 to 24 years were included. The median age was 16 years. The median CD4 cell count
was 650.6 cells/mm3 (IQR 350.7-884.0). More than half (60.6%) of AYA had a CD4 cell count higher than 500 cells/mm3.
Overall, 76.9% of AYA had achieved viral suppression (viral load <1000 copies/ml). There was a significant increase in
virologic failure with higher age and late adolescents and young adults were more likely to have a viral load > 1000 copies/
Conclusion: The overall virologic suppression in this cohort of AYA was sub-optimal. Both immunological and virologic
outcomes were worse among late adolescents (18-19 years) and young adults (20-24 years).
Adolescents; HIV; Kenya; virologic suppression; young adults.