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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 21, No. 1, 2021, pp. 96-104
Bioline Code: hs21026
Full paper language: English
Document type: Research Article
Document available free of charge

African Health Sciences, Vol. 21, No. 1, 2021, pp. 96-104

 en Monocyte-to-HDL-cholesterol ratio is associated with Ascending Aorta Dilatation in Patients with Bicuspid Aortic Valve
Acar, Burak; Yayla, Cagrı; Gul, Murat; Karanfil, Mustafa; Unal, Sefa; Uçar, Fatih; Kuyumcu, Serdar Mevlut; Ertem, Ahmet Goktug; Ozen, Yasin; Ozbay, Mustafa Bilal; Ozeke, Ozcan & Aydogdu, Sinan

Abstract

Background: The importance of monocyte count-to-HDL-cholesterol ratio (MHR) in cardio- vascular diseases has been shown in various studies. Ascending aortic dilatation (AAD) is a common complication in the patients with bicuspid aortic valve. In this study, we aimed to investigate the relationship between MHR and the presence of aortic dilatation in the patients with bicuspid aortic valve.
Methods: The study population included totally 347 patients with bicuspid aortic valve.169 patients with aortic dilatation (ascending aorta diameter ≥ 4.0 cm) and 178 patients with no aortic dilatation. Echocardiographic and laboratory measurement was done and compared between groups.
Results: The mean age of the participants was 44.7 ± 15.4 years and average ascending aorta diameter was 3.2 ± 0.3 cm in dilatation negative group and 4.4 ± 0.4 cm in positive group. MHR was significantly increased in in patients with aortic dilatation. MHR and uric acid level was independently associated with the presence of aortic dilatation in the patients with bicuspid aortic valve.
Conclusion: We found a significant relationship between MHR and aortic dilatation in the patients with bicuspid aortic valve.

Keywords
Bicuspid aorta; aorta aneurysm; monocyte HDL ratio; inflammation.

 
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