African Health Sciences
Makerere University Medical School
Vol. 21, No. 1, 2021, pp. 96-104
Bioline Code: hs21026
Full paper language: English
Document type: Research Article
Document available free of charge
African Health Sciences, Vol. 21, No. 1, 2021, pp. 96-104
© Copyright 2021 - Acar B et al.
Monocyte-to-HDL-cholesterol ratio is associated with Ascending Aorta Dilatation in Patients with Bicuspid Aortic Valve|
Acar, Burak; Yayla, Cagrı; Gul, Murat; Karanfil, Mustafa; Unal, Sefa; Uçar, Fatih; Kuyumcu, Serdar Mevlut; Ertem, Ahmet Goktug; Ozen, Yasin; Ozbay, Mustafa Bilal; Ozeke, Ozcan & Aydogdu, Sinan
Background: The importance of monocyte count-to-HDL-cholesterol ratio (MHR) in cardio- vascular diseases has been
shown in various studies. Ascending aortic dilatation (AAD) is a common complication in the patients with bicuspid aortic
valve. In this study, we aimed to investigate the relationship between MHR and the presence of aortic dilatation in the patients
with bicuspid aortic valve.
Methods: The study population included totally 347 patients with bicuspid aortic valve.169 patients with aortic dilatation
(ascending aorta diameter ≥ 4.0 cm) and 178 patients with no aortic dilatation. Echocardiographic and laboratory measurement
was done and compared between groups.
Results: The mean age of the participants was 44.7 ± 15.4 years and average ascending aorta diameter was 3.2 ± 0.3 cm
in dilatation negative group and 4.4 ± 0.4 cm in positive group. MHR was significantly increased in in patients with aortic
dilatation. MHR and uric acid level was independently associated with the presence of aortic dilatation in the patients with
bicuspid aortic valve.
Conclusion: We found a significant relationship between MHR and aortic dilatation in the patients with bicuspid aortic
Bicuspid aorta; aorta aneurysm; monocyte HDL ratio; inflammation.