Indian scenario of IgA nephropathy: a systematic review and meta-analysis|
Background: IgA nephropathy (IgAN) is most common primary glomerulopathy. There are variations in prevalence of
IgAN and its clinical features in different studies from India.
Aim: To summarize overall scenario of IgAN in India.
Methods: In this systematic review, studies related to IgAN and related renal disease were included. Data searched were
PubMed, EMBASE, Google scholar, and Cochrane Database from inception to 31st January 2019
Results: Total 49 studies (N=2480) were included: 21studies (N=2309) of primary IgAN; 19 studies (N=21) of Secondary
IgAN; four studies (N=133) of IgA vasculitis nephropathy (IgAVN); and five studies (N=17) of IgA dominant nephropathy
(IgADN). Prevalence of IgAN was 16.5% in India. Age of affected persons was ranging from 27.2±16.7 to 48.6±21.3 years
. Male female ratio was 1.8:1. Clinical features of Primary IgAN, IgAVN, IgADN & Secondary IgAN were microscopic
hematuria (49.6%, 44.4%, 15.6% & 59.5%), macroscopic hematuria (5.1%, 0.4%,40.9%,& 35.7%), Subnephrotic proteinuria
(42.1%, 29.4%, 23.2%, & 52.3%), nephrotic proteinuria (16.0%, 4.4%, 76.8%,& 47.6%), and hypertension (25.8%,18.3%,
35.5%,& 47.6%).. The 24 hours proteinuria was ranging from 2.6±1.5 to 4.7±2.3 gm/day and serum creatinine (mg/dl)
was ranging from 0.9±0 to 3.5±3.9 mg/dl. Histolomorphologically, all type of IgAN showed mesangial hypercellularity
and Immunofluorescence revealed IgA deposition..
Conclusion: The overall prevalence of primary IgAN in India was 16.5%. The subnephrotic proteinuria and microscopic
hematuria were common clinical features.
IgA Nephropathy; histomorphology; prevalence; India.