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Journal of Applied Sciences and Environmental Management
World Bank assisted National Agricultural Research Project (NARP) - University of Port Harcourt
ISSN: 1119-8362
Vol. 13, No. 3, 2009, pp. 5-8
Bioline Code: ja09030
Full paper language: English
Document type: Research Article
Document available free of charge

Journal of Applied Sciences and Environmental Management, Vol. 13, No. 3, 2009, pp. 5-8

 en Investigation on the Methaemoglobin Concentration of Three Human Erythrocyte Genotypes Infected With Plasmodium falciparum check for this species in other resources .
Chikezie, P. C.; Chikezie, C. M.; Uwakwe, A. A. & Monago, C. C.


Investigation to ascertain the levels of methaemoglobin concentration of three human erythrocyte genotypes (HbAA, HbAS and HbSS) obtained from apparently healthy and clinically confirmed malarious subjects/volunteers was carried out. Spectrophotometric method was used for the determination of erythrocyte methaemoglobin concentration. The mean (+S.D) methaemoglobin concentration, expressed as percentage (Met.Hb %) of total haemoglobin concentration of three erythrocyte was in the order: HbAA0.05) between methaemoglobin concentrations of HbAA and HbAS erythrocyte of nonmalarious human subjects/volunteers. Erythrocyte obtained from blood sample of malarious human subjects/volunteers exhibited significantly (p<0.05) higher levels of methaemoglobin concentrations than those of non-malarious individuals, irrespective of their genotype and gender. In a similar manner, P. falciparum infected erythrocyte of malarious male individuals contained significantly (p<0.05) higher methaemoglobin concentration than the female group. Furthermore, with exception of HbAS erythrocytes, the other two red cell genotypes (HbAA and HbSS) showed significant difference (p<0.05) in methaemoglobin content between malarious male and female subjects/volunteers. The study suggests that erythrocyte methaemoglobin evaluation might be a reliable biochemical marker and possess promising rational for diagnostic potential in malaria. @ JASEM

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