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Journal of Applied Sciences and Environmental Management
World Bank assisted National Agricultural Research Project (NARP) - University of Port Harcourt
ISSN: 1119-8362
Vol. 13, No. 4, 2009, pp. 51-54
Bioline Code: ja09057
Full paper language: English
Document type: Research Article
Document available free of charge

Journal of Applied Sciences and Environmental Management, Vol. 13, No. 4, 2009, pp. 51-54

 en Acalypha wilkesiana Muell Arg Induced Diuresis in Salt-Loaded Rats: Implications for the Management of Edema, Obesity and Hypertension
Ikewuchi, Chigozie Jude; Ikewuchi, Chidinma Catherine & Onwuka, Chukwuma Francis


Effect of the leaves on the weight, urine output, and plasma and urine chemistry of salt-loaded rats was investigated. The control group received a diet consisting 100% of the commercial feed; the test-control received a diet consisting 8% salt and 92% commercial feed, while the test received diet containing 8% salt, 5% leaf powder and 87% commercial feed. There was no significant difference in the food intake of the three groups, although the weight change of the test animals was significantly lower (p<0.05) than the other two groups. The time course of the mean daily urine output per rat revealed an initial diuretic impact of the leaves, to a level that was sustained through to the sixth week, while there was a gradual/steady increase in the urine output of the test-control. There was no significant difference in the plasma acetone, albumin and creatinine concentrations of the test and test-control, while the plasma sugar concentration of the test was significantly (p<0.05) the least. The leaves had no effect on urinary excretion of acetone, potassium and creatinine, but significantly lowered (p<0.05) the albumin and increased the sodium excretion. @JASEM

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