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Journal of Applied Sciences and Environmental Management
World Bank assisted National Agricultural Research Project (NARP) - University of Port Harcourt
ISSN: 1119-8362
Vol. 15, No. 3, 2011, pp. 451-454
Bioline Code: ja11075
Full paper language: English
Document type: Research Article
Document available free of charge

Journal of Applied Sciences and Environmental Management, Vol. 15, No. 3, 2011, pp. 451-454

 en Synthesis and Biological Activities of Some Benzimidazoles Derivatives
Al-Ebaisat, Hamdan S.

Abstract

A set of six novel benzimidazoles compounds were prepared, this includes 5- Nitro-2-phenyl -1-ethylbenzimidazol (5),2-(p-Bromophenyl)-5-nitro-1-ethylbenzimidazol (6), 2- (p- Bromophenyl- 5-nitro-1–cyclopentylbenzimidazol(7),2-(p-Bromophenyl)-5-nitro-1- cyclopentylbenzimidazol (8),5-Amino-2-(p-Bromophenyl)-1-ethylbenzimidazol (9), and 5-Amino- (2- (p- Bromophenyl)- 1- cyclopentylbenzimidazol (10). The chemical structures of these compounds were elucidated using NMR and elemental analysis. The biological activity of these compounds as fungicides was tested against three commercially known fungicides ( Candida albicans check for this species in other resources , patient isolate Candida glabrata check for this species in other resources and Candida krusei check for this species in other resources ).The biological activity of two compounds was found to be comparable to that of the commercially available fungicides (6 and 9).

Keywords
Benzimidazole; Antifungal Agent; Fungicides; Aldehyde; Derivative; Chemical Synthesis.

 
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