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Journal of Applied Sciences and Environmental Management
World Bank assisted National Agricultural Research Project (NARP) - University of Port Harcourt
ISSN: 1119-8362
Vol. 17, No. 4, 2013, pp. 603-607
Bioline Code: ja13068
Full paper language: English
Document type: Research Article
Document available free of charge

Journal of Applied Sciences and Environmental Management, Vol. 17, No. 4, 2013, pp. 603-607

 en Cola Rostrata check for this species in other resources : Phytochemical and Toxicity Studies
ODION, EMMANUEL EIMIOMODEBHEKI; POH, CHING FIDELIS; FALODUN, ABIODUN & ADELUSI, SUNDAY ADEWALE

Abstract

Cola species are used in folk medicine as stimulant, to prevent vomiting, dysentery and suppress sleep. Proximate analysis and phytochemical screening were evaluated using standard methods while acute toxicity study of the crude extract of Cola rostrata check for this species in other resources on swiss albino mice was evaluated by administration of the crude extract. Phytochemical screening showed the presence of flavonoid, phenols, saponin, steroid, tannins, triterpenoid and reducing sugar. The proximate analysis gave moisture content (10.23 ± 0.55 %), total ash value (13.39 ± 0.048 %), acid insoluble ash (2.50 ± 0.18%), water insoluble ash (11.26 ± 0.40%), alcohol soluble extractive (0.86 ± 0.11%) and water soluble extractive (1.44 ± 0.05%). Result of acute toxicity study did not show mortality at 8 g/kg p.o after 24 hours of administration and there was no sign of toxicity or mortality after 14 days of observation. In conclusion, the root bark of C. rostrata contains phytochemicals and safe on the basis of acute toxicity testing of the crude extract.

Keywords
Cola rostrata, phytochemicals, proximate analysis, acute toxicity study

 
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