The toxic effects of aluminium Chloride (AlCl3) in albino rats (
Rattus
norvegicus
) have been studied. The species weighing 250 ± 20g were administered varying
concentrations of the LD
50 (3630mg/kg body weight), ½ LD
50 (1815mg/kg body weight) and ¼
LD
50 (907.5 mg/kg body weight) of aluminium Chloride solution orally as drinking water for six
weeks after which it was discontinued. The specimens were grouped into three. The first group
was administered the various concentrations of (AlCl
3) with no abatement, while the second and
third groups were administered the same concentrations of (AlCl
3) as the former but were fed
respectively with 20% and 50% by weight of aqueous leaf extract of
Annona Muricata
mixed
with their feeds for six weeks as abatement. Blood samples were collected for biochemical
analysis. The results showed significant increase in the levels of urea, creatine, aspartate
aminotransferase (AAT), alkaline phosphatase (ALP), alanine aminotransferase (ALAT), total
glyceride, total bilirubin, total cholesterol and glucose levels (P<0.05). However, significant
decrease in the levels of these parameters was observed with the application of
A. muricata.
This reveals the potency of
A. muricata leaves to abate the effects of the poison in the kidney
and liver of mammals.