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Journal of Applied Sciences and Environmental Management
World Bank assisted National Agricultural Research Project (NARP) - University of Port Harcourt
ISSN: 1119-8362
Vol. 18, No. 2, 2014, pp. 205-208
Bioline Code: ja14028
Full paper language: English
Document type: Research Article
Document available free of charge

Journal of Applied Sciences and Environmental Management, Vol. 18, No. 2, 2014, pp. 205-208

 en Synthesis, Characterization and Antimicrobial Activities of Some Nicotinamide – metal
LAWAL, A.; OBALEYE, J.A.; ADEDIJI, J.F.; AMOLEGBE, S.A.; BAMIGBOYE, M.O. & YUNUS- ISSA, M.T.

Abstract

Some transition metal complexes of nicotinamide have been prepared and characterized using melting point, conductivity measurement, infrared, electronic, HNMR and atomic absorption spectroscopic methods. The antibacterial and antifungal studies of the metal complexes and the ligand have been evaluated against Escherichia coli check for this species in other resources , Staphylococcus check for this species in other resources and Bacillus subtilis check for this species in other resources , Aspergillus flavus check for this species in other resources , Aspergillus niger check for this species in other resources and penicillum check for this species in other resources species. It was found that nicotinamide formed stable metal complexes with these metal ions. The analysis of the spectroscopic data shows that nicotinamide act as monodentate, coordinating through the nitrogen atom of the pyridine ring. All the complexes exhibit 4- coordinate geometry. The results of the antimicrobial studies showed that the metal complexes have higher inhibitory activity than the original nicotinamide against the tested bacteria and fungi species.

Keywords
Synthesis; Metal complexes; Nicotinamide; Antibacterial; Antifungal

 
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