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Journal of Applied Sciences and Environmental Management
World Bank assisted National Agricultural Research Project (NARP) - University of Port Harcourt
ISSN: 1119-8362
Vol. 19, No. 2, 2015, pp. 169-175
Bioline Code: ja15022
Full paper language: English
Document type: Research Article
Document available free of charge

Journal of Applied Sciences and Environmental Management, Vol. 19, No. 2, 2015, pp. 169-175

 en Anti-Diarrheal Activity of the Aqueous Leaf Extract of Ageratum Conyzoides check for this species in other resources in Wistar Rats
EMUDAINOHWO, J.O.T.; ERHIRHIE, E.O. & MOKE, E.G.

Abstract

The leaves of Ageratum conyzoides check for this species in other resources had been reportedly used in traditional medicine in the treatment of diarrhea. Thus its aqueous leaf extract was investigated for its possible anti-diarrheal property using castor oil induced diarrheal, charcoal meal intestinal transit and castor oil-induced enteropooling models in Wistar rats to substantiate its folklore claim. In castor oil induced diarrheal model, 500 mg/kg and 1000 mg/kg body weight doses of the extract showed dose dependent remarkable anti-diarrheal activity evidenced by delay in diarrheal latency, reduction in the rate of defecation and consistency, although it was not comparable to that loperamide which elicited absent of diarrheal. In charcoal meal intestinal transit models, extract doses (500 mg/kg and 1000 mg/kg) also elicited dose dependent anti-diarrheal activity, evidenced by reduction in distance travelled by charcoal meal. Although, it was not also comparable to that of intraperitoneal injection of standard drug, Atropine sulphate at a dose of 0.1 mg/kg body weight. Experimental findings showed that aqueous leaf extract of Ageratum conyzoides possess anti-diarrheal activity and may be a potential source of anti-diarrheal drug in future. Higher doses may possess better anti-diarrhoeal properties.

Keywords
Ageratum conyzoides; anti-diarrheal activity; loperamide; castor oil; atropine sulphate; activated charcoal; enteropooling; Wistar rats

 
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