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Journal of Applied Sciences and Environmental Management
World Bank assisted National Agricultural Research Project (NARP) - University of Port Harcourt
ISSN: 1119-8362
Vol. 20, No. 2, 2016, pp. 396-400
Bioline Code: ja16048
Full paper language: English
Document type: Research Article
Document available free of charge

Journal of Applied Sciences and Environmental Management, Vol. 20, No. 2, 2016, pp. 396-400

 en Hepatoprotective Effects of Ethanol Extract of Caesalpinia bonduc check for this species in other resources against Carbon Tetrachloride Induced Hepatotoxicity in Albino Rats.
UBHENIN, A.E.; IGBE, I.; ADAMUDE, F.A. & FALODUN, A.

Abstract

The present study was carried out to evaluate the acute toxicity, hepatoprotective and in-vivo antioxidant activities of ethanolic extract of Caesalpinia bonduc check for this species in other resources leaf on carbon tetrachloride (CCl4) induced liver damage using Swiss albino rats. The ethanolic extract of the plant of C. bonduc were suspended in 5 % tragacanth and then administered orally at doses of 250 and 500 mg/kg body weight for fourteen days before intraperitoneally injection of Carbon tetrachloride (CCl4) at dose of 2 mL/kg body weight. The plant extracts at 250 and 500mg/kg b.wt showed a remarkable hepatoprotective and invivo antioxidant activities against carbon tetrachloride CCl4 – induced hepatotoxity judged from the serum marker enzymes .The CCl4 induced significant increase in aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phophatase (ALP), total bilirubin, and malondyaldehyde (MDA) with a reduction of total protein, catalase, and glutathione peroxidase. Treatment of rats with different doses of plant extract (250 and 500 mg/kg b.wt.) significantly (P< 0.001) altered serum maker enzymes and antioxidant levels to near normal levels. The study suggests that C. Bonduc specifically chloroform and ethyl acetate fraction may be good sources of natural antioxidant and hepatoprotective substance.

Keywords
Ceasalpiniabonduc; hepatoprotective; intraperitoneally; antioxidant

 
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