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Synthesis and Spectroscopic Analysis of Schiff Bases of Imesatin and Isatin Derivatives OGUNTOYE, OLUBUNMI S.; HAMID, ABDULMUMEEN A.; ILOKA, GABRIEL S.; BODEDE, SUNDAY O.; OWALUDE, SAMSON O. & TELLA, ADEDIBU C. Abstract A series of new Schiff bases of Imesatin and Isatin derivatives which have been previously prepared from the reaction of Hydrazine monohydrate, p-phenylenediamine and 4,4- diaminodiphenylmethane with Isatin were reported. The compounds were characterized by elemental analyses, UV-visible, Infrared and Nuclear Magnetic Resonance (1H NMR and 13C NMR) spectroscopic analyses. The synthesized Schiff bases were obtained in moderate to excellent yields between 55.3 – 89.3%. Infrared spectra of all synthesized compounds contain the characteristic azomethine linkage (-CH=N) between 1580 – 1630 cm-1 and the N–H of the Isatin ring signals between δ 8.32 – 10.68 ppm in their 1H NMR spectra. The present work affords reaction pathway that is efficient and operational simplicity for the synthesis of Schiff bases derivatives. @JASEM Keywords Schiff bases; isatin; imesatin; spectroscopic analysis; biological activity

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