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Journal of Applied Sciences and Environmental Management
World Bank assisted National Agricultural Research Project (NARP) - University of Port Harcourt
ISSN: 1119-8362
Vol. 20, No. 4, 2016, pp. 1157-1161
Bioline Code: ja16125
Full paper language: English
Document type: Research Article
Document available free of charge

Journal of Applied Sciences and Environmental Management, Vol. 20, No. 4, 2016, pp. 1157-1161

 en Synthesis, Characterization and Biological Activity Studies of Mixed Paracetamol- Ascorbic Acid Metal Complexes.
BABAMALE, H.F.; LAWAL, A.; RAJEE, O.A. & OLOYEDE, E.A.

Abstract

Mixed ligand-metal complexes of Paracetamol and Ascorbic acid were synthesized using FeCl2.4H2O, CuCl2.2H2O, NiCl2.6H2O, CoCl2.6H2O and ZnSO4 salts based on two concentrations (3mmol and 5mmol). The complexes were characterized using some physical techniques such as melting point, solubility, conductivity measurement and spectroscopic analyses such as UV-Visible spectroscopy, Atomic absorption spectroscopy, and Infrared spectroscopy. Based on the physical and spectroscopic results, the coordination of the metal was through the phenolic oxygen and carbonyl oxygen in paracetamol while it was through the carbonyl oxygen and C-2 hydroxyl group in ascorbic acid. The complexes were also screened for their antimicrobial activities against some isolates of Enterococcus faecalis check for this species in other resources , Staphylococcus aureus check for this species in other resources , Clostridium difficile check for this species in other resources , Klebsiella sp. check for this species in other resources , Helicobacter pylori check for this species in other resources .

Keywords
Metal; Mixed ligand-metal complexes; Paracetamol; Ascorbic acid; Isolates

 
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