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Journal of Applied Sciences and Environmental Management
World Bank assisted National Agricultural Research Project (NARP) - University of Port Harcourt
ISSN: 1119-8362
Vol. 21, No. 5, 2017, pp. 821-825
Bioline Code: ja17090
Full paper language: English
Document type: Research Article
Document available free of charge

Journal of Applied Sciences and Environmental Management, Vol. 21, No. 5, 2017, pp. 821-825

 en Analgesic and Anti-inflammatory Effects of the Aqueous Leaf Extract of Dichrostachys cinerea check for this species in other resources
OKHUAROBO, AGBONLAHOR; GODSWILL, NWAMAIFE & OZOLUA, RAYMOND

Abstract

In this present study, the analgesic activity of the aqueous extract of the leaves of Dichrostachy cinerea was investigated in mice using acetic acid-induced writhing and hot plate test, while the anti-inflammatory activity was investigated in rats using the carrageenan and dextran- induced paw edema. The extract (400, 800mg/kg) exhibited a dose dependent inhibition of abdominal writhing in mice compared to control. The effects of the extract were not significantly different from that of aspirin. The extract (800mg/kg) caused a significant (p<0.01) increase in pain threshold, at 60th minute post treatment in the hot plate test and the effects of the extract were lower than that of morphine (4mg/kg). The extract (800mg/kg) and indomethacin (10mg/kg) at 1st hour and 2nd - 4th hour produced inhibitions of the carrageenan-induced paw oedema versus control. The results also showed that the extract (800mg/kg) produced inhibition of dextran- induced paw edema between 2nd hour and 4th hour compared to control. Overall, our data suggest that the extract possesses anti-inflammatory and analgesic effects, which may be mediated solely by peripheral mechanisms.

Keywords
Dichrostachys Cinerea; analgesic; anti-inflammatory; hot plate; dextran; carragenan; edema; pain.

 
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