Fifteen (15) male Wistar rats were completely randomized into three (3) groups. Group A was normal
control, Group B received 200 mg/kg weight of ethyl acetate extract of
Annona muricata leaves (AMLE) and Group C
received 100 mg/kg b.weight AMLE. Single daily dose of AMLE was administered orally for twenty one (21) days after
which the animals were sacrificed. The blood samples were taken for haematological and biochemical analysis.
Antibacterial and antifungal activities of n-hexane, ethyl acetate and methanol extracts of
Annona muricata leaves were
carried out. These extracts exhibited satisfactory inhibitory activities against bacterial and fungal strains, which include;
Staphylococcus aureus
,
Escherichia coli
,
Bacillus subtilis
,
Pseudomonas aeruginosa
,
Salmonella typhi
,
Klebsiellae pneumonae
,
Candida albicans
,
Aspergillus niger
,
penicillium notatum
and
Rhizopus stolonifer
. N-hexane extract of the
plant exhibited antioxidant property by scavenging DPPH radicals with IC
50 of 342.44 μg/mL. GC-MS analysis of nhexane,
ethyl acetate and methanol extracts of the plant principally revealed the presence of Urs-12-ene (23.15%),
Squalene (48.80%) and Clionasterol (15.88%) respectively.
