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Journal of Applied Sciences and Environmental Management
World Bank assisted National Agricultural Research Project (NARP) - University of Port Harcourt
ISSN: 1119-8362
Vol. 21, No. 6, 2017, pp. 1197-1201
Bioline Code: ja17149
Full paper language: English
Document type: Research Article
Document available free of charge

Journal of Applied Sciences and Environmental Management, Vol. 21, No. 6, 2017, pp. 1197-1201

 en Biochemical Properties, In-Vitro Antimicrobial, and Free Radical Scavenging Activities of the Leaves of Annona muricata check for this species in other resources
LAWAL, Z A; HAMID, A A; SHEHU, A; GOD’SHELP, E; AJIBADE, O S; ZUBAIR, O A; OGHENEOVO, P; MUKADAM, A A & ADEBAYO, C T

Abstract

Fifteen (15) male Wistar rats were completely randomized into three (3) groups. Group A was normal control, Group B received 200 mg/kg weight of ethyl acetate extract of Annona muricata leaves (AMLE) and Group C received 100 mg/kg b.weight AMLE. Single daily dose of AMLE was administered orally for twenty one (21) days after which the animals were sacrificed. The blood samples were taken for haematological and biochemical analysis. Antibacterial and antifungal activities of n-hexane, ethyl acetate and methanol extracts of Annona muricata leaves were carried out. These extracts exhibited satisfactory inhibitory activities against bacterial and fungal strains, which include; Staphylococcus aureus check for this species in other resources , Escherichia coli check for this species in other resources , Bacillus subtilis check for this species in other resources , Pseudomonas aeruginosa check for this species in other resources , Salmonella typhi check for this species in other resources , Klebsiellae pneumonae check for this species in other resources , Candida albicans check for this species in other resources , Aspergillus niger check for this species in other resources , penicillium notatum check for this species in other resources and Rhizopus stolonifer check for this species in other resources . N-hexane extract of the plant exhibited antioxidant property by scavenging DPPH radicals with IC50 of 342.44 μg/mL. GC-MS analysis of nhexane, ethyl acetate and methanol extracts of the plant principally revealed the presence of Urs-12-ene (23.15%), Squalene (48.80%) and Clionasterol (15.88%) respectively.

Keywords
biochemical properties; antimicrobial; antioxidant; urs-12-ene; squalene; clionasterol

 
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