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Journal of Applied Sciences and Environmental Management
World Bank assisted National Agricultural Research Project (NARP) - University of Port Harcourt
ISSN: 1119-8362
Vol. 22, No. 7, 2018, pp. 1089-1095
Bioline Code: ja18186
Full paper language: English
Document type: Research Article
Document available free of charge

Journal of Applied Sciences and Environmental Management, Vol. 22, No. 7, 2018, pp. 1089-1095

 en Mathematical Model for Ebola Virus Infection in Human with Effectiveness of Drug Usage
LASISI, NO; AKINWANDE, NI; OLAYIWOLA, RO & COLE, AT

Abstract

In this paper, we formulated a mathematical model of the dynamics of Ebola virus infection incorporating effectiveness of drug usage. The infection free and infection persistence equilibrium points were obtained. The control reproduction number was obtained which was used to analyse the local and global stability of the infectionfree equilibrium. Using the method of linearization, the infection-free equilibrium (IFE) state was found to be locally asymptotically stable if Rc < 1 and unstable if Rc > 1. By constructing lyapunov function, the infection-free equilibrium was found to be globally asymptotically unstable if Rc > 1. Numerical simulation of the model was done. It is observed that, as percentage of effectiveness of drug administration increases, the control reproduction number decreases. This suggests that with the help of drugs usage, the immunes system have the ability to suppress the increase of infected cells, as well as virus load which shown that the virus does not maintain an infection in the system.

Keywords
Drug Usage; Ebola virus; Global stability; Immune response; Mathematical model

 
© Copyright 2018 - Lasisi et al.

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