A double alkynylation of quinoline-5,8-dione to furnished bis-alkynylquinoline-5,8-dione in good
yields and their in silico and antimicrobial studies is described. This was achieved by cross-coupling of 6,7-
dibromoquinoline-5,8-dione with various terminal alkynes in the presence of bis(triphenylphosphine) palladium(II)
chloride as a pre-catalyst and tetrabutyl ammonium fluoride trihydrate. The structures of the synthesised compounds were
confirmed by UV/Visible, Fourier Transform-Infrared and
1H and
13C-NMR spectral data. The synthesised compounds
exhibited good activity against
Escherichia Coli
1,
Escherichia Coli 12,
Klebsiella Pneumonia
,
Pseudomonas aeroginosa
and
Staphylococcus aureus
compare to the gentamycin and ampicillin. Molecular docking simulation study of the binding
interactions of compounds with receptors disclosed significant binding affinity for
P. aeruginosa LpxC than the
E. coli
glutaredoxin.
