Antimalarial Efficacy and Chemopreventive Capacity of Bamboo Leaf ( Bambusa vulgaris ) in Malaria Parasitized Mice|
The exploration of natural products for the treatment of malarial has been the main focus of scientists
in the past decades. In this research, the phytochemical constituents, antimalarial effect, and chemopreventive capacity of
aqueous leaf extract of Bambusa vulgaris in malaria parasitized mice was investigated. A total of 30 male mice, grouped
into six (n=5), was used. The results obtained showed that B. vulgaris is rich in flavonoid (262.08 μg CE/g) and phenol
(0.91 g AAE/ 100 g). There was significant reduction on the activities of serum alanine aminotransferase (ALT), aspartate
aminotransferase (AST), alkaline phosphatase (ALP) and Gamma glutarmyl-transferase (GGT) upon treatment as
compared with the control groups (P<0.05). Concentration of total bilirubin (TB), direct bilirubin (DB) and serum
electrolytes (sodium, calcium, phosphorus and chloride) decreased in treated groups; serum urea, creatinine and uric acid
also reduced significantly as against the control groups (P<0.05). The hepatoprotection and renal function restoration
observed upon the administration of the plant extract indicate to a far reaching end that B. vulgaris leaf extract would be
a promising natural antimalarial product devoid of side effects upon use, especially when administered within the dose
range of 100 – 200 mg/Kg body weight investigated in this study.
Bambusa vulgaris; phytochemicals; antimalarial; chemoprevention.