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Journal of Applied Sciences and Environmental Management
World Bank assisted National Agricultural Research Project (NARP) - University of Port Harcourt
ISSN: 1119-8362
Vol. 22, No. 11, 2018, pp. 1733-1736
Bioline Code: ja18291
Full paper language: English
Document type: Research Article
Document available free of charge

Journal of Applied Sciences and Environmental Management, Vol. 22, No. 11, 2018, pp. 1733-1736

 en Synthesis, Characterization and Antimicrobial of Schfiff Base from 5-Bromo – Salicylaldehyde and P-Toluidine
OBASUYI, EI & IYEKOWA, O

Abstract

As pathogens in recent times have developed resistance to the existing antibiotics, the demand for new and more effective antimicrobial agents is a continuous phenomenon. The study involves the synthesis of schiff base from 5-bromo- salicylaldehyde and para-toluidine.The synthesized compounds (5-Bromo – Salicylaldehyde and the Schiff base-N-(5-bromo-2-hydroxybenzylidene) Para-toluidine) were evaluated for antimicrobial activities against different bacteria strains using the agar well diffusion method. The 5-bromosalicylaldehyde and its Schiff base indicated dose dependent activity as concentration increases from 125mg/ml to 1000mg/ml and inhibitory zones were found to increase mostly for Escherichia coli check for this species in other resources . The two compounds synthesized have indicated high antimicrobial activities on the selected germs and as such can be a drug precursor to microbial infections with further research.

Keywords
schiff base; 5-bromo- salicylaldehyde; para-toluidine; antimicrobial activity

 
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