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Effect of Tamsulosin Use on Plasma Insulin Status in Benign Prostatic Hyperplasia Patients in Sokoto, Nigeria
DIKKO, M; BELLO, SO; CHIKA, A; MUNGADI, IA; SARKINGOBIR, Y & UMAR, AI
Abstract
The objective of this paper was to determine the effect of tamsulosin use on plasma insulin status in
benign prostatic hyperplasia (BPH) patients in Sokoto, Nigeria. Standard methods and procedures were used. At 2nd and
3rd months of tamsulosin use, there was a significant increase (P<0.05) in plasma insulin values compared to baseline.
Likewise, at 4th month of tamsulosin use, a significant increase (P<0.05) in plasma insulin values was revealed compared
to baseline and 2nd month values. Other inter-mean values comparisons were not significantly different (P>0.05). Plasma
insulin at 4th months of the study in BPH patients (45-54 years) treated with tamsulosin revealed a significant increase
(P<0.05) compared to baseline values. Other inter-mean values comparisons were not significantly different (P>0.05).
BPH patients (aged 55-64 years) at 3rd month showed a significant increase (P<0.05) in plasma insulin values compared
to baseline values. Likewise, at 4th month of tamsulosin use, a significant increase (P<0.05) in plasma insulin values was
seen compared to baseline and 1st month values. Other inter-mean values comparisons were not significantly different
(P>0.05). In BPH patients aged 65 and above, there was no significant difference (P>0.05) in plasma insulin values from
1st through 4th month compared to baseline and other inter mean values comparisons. Plasma insulin at 0th , 1st , 2nd , 3rd
and 4th months of BPH patients of different age groups treated with tamsulosin revealed no significant differences
(P>0.05). This study revealed that tamsulosin use in the patients lead to significant increase in plasma insulin level
(hyperinsulinemia). Careful and routine monitoring of BPH patients should be done. Patients need enough exercise
activities and some drugs can be administered to alleviate elevated glucose or insulin.
Keywords
Tamsulosin; hyperinsulinemia; benign prostatic hyperplasia patients; insulin resistance
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