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African Journal of Health Sciences
The Kenya Medical Research Institute (KEMRI)
ISSN: 1022-9272
Vol. 13, No. 1-2, 2006, pp. 33-39
Bioline Code: jh06006
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Health Sciences, Vol. 13, No. 1-2, 2006, pp. 33-39

 en Antiplasmodial Activities of Some Products from Turreanthus Africanus check for this species in other resources (Meliaceae)
Ngemenya, Moses N.; Akam, Thomas M.; Yong, Joseph N.; Tane, Pierre; Fanso-Free, Samuel N. Y.; Berzins, Klavs & Titanji, Vincent P. K.

Abstract

We investigated the antiplasmodial activity of some pure compounds of Turreanthus africanus check for this species in other resources (Meliaceae), a plant that is used in traditional medicine to treat malaria in Southwest Cameroon. A phytochemical analysis of the methylene chloride: methanol (1:1) extract of the seeds of the plant yielded seven compounds. Four of them, which were oils, were subjected to in vitro bioassays on Plasmodium falciparum check for this species in other resources F 32, chloroquine sensitive strain. Compound 1 (16-oxolabda-8 (17), 12(E)-dien-15-oic acid), showed the highest antiplasmodial activity, two others (methyl-14,15-epoxylabda-8 (17), 12(E)-diene-16-oate, and turreanin A), had moderate activity and one was inactive. These findings are consistent with the use of T. africanus in the traditional treatment of P. falciparum malaria.

 
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