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African Journal of Health Sciences
The Kenya Medical Research Institute (KEMRI)
ISSN: 1022-9272
Vol. 13, No. 1-2, 2006, pp. 47-54
Bioline Code: jh06008
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Health Sciences, Vol. 13, No. 1-2, 2006, pp. 47-54

 en Influence of Age of Mice on the Susceptibility to Murine Schistosomiasis Infection
Yole, Dorcas S.; Gikuru, Stephen K.; Wango, Emmanuel O.; Kithome, Kiio; Kiarie, Simon & Limo, Moses


Intensity of human schistosomiasis infection increases with age, a peak being attained at early puberty. Hormones could be involved in the age-related changes in susceptibility to schistosomiasis. Male BALB/c mice were infected with Schistosoma mansoni check for this species in other resources either before or after puberty and worm numbers, cellular immune responses, hormonal levels and pathology analysed. Pre-puberty infected mice had a significantly higher number of adult worms (p<0.05), more severe granulomas, higher mortality rate and higher proliferative responses as compared to postpuberty infected mice. Levels of the hormones were lower in the pre-puberty infected mice as compared to the post-puberty group early in the infection. Plasma levels of testosterone and luteinizing hormones decreased significantly (p<0.05) in infected mice when compared to controls. Susceptibility to S. mansoni in male BALB/c mice seems to be influenced by levels of testosterone and leutenizing hormone at infection. Albeit, an infection with S. mansoni seems to lower the hormonal levels.

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