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Journal of Medicine and Biomedical Research
College of Medical Sciences, University of Benin
ISSN: 1596-6941
Vol. 7, No. 1-2, 2008, pp. 45-50
Bioline Code: jm08007
Full paper language: English
Document type: Research Article
Document available free of charge

Journal of Medicine and Biomedical Research, Vol. 7, No. 1-2, 2008, pp. 45-50

 en Preliminary Study on The Effect of Medicinal Mushroom Extract and Timolol Maleate on Dexamethasone Induced Ocular Hypertension in Feline's Eye Model
Ayoakin, Akinlabi Ghalib; Eghosasere, Igbinigie Vivian; Oluwadare, Akpaja Emmanuel & Iyawe, Vincent

Abstract

Mushrooms are like mannas and their water heal eye diseases. To determine if aqueous mushroom extract has an effect on ocular hypertension, 8 cats with baseline intra ocular pressure (IOP) of 14.94 ± 0.153mmHg were used in the first phase of this study. The second phase consisted of 2 groups, the experimental and the control groups. The control consisted of 2 cats (4 eyes) while the experimental consisted of 6 cats (12 eyes). Ocular hypertension was induced in the experimental group with 0.1% dexamethasone treatment (2 drops q.i.d x 1/12) and IOP measurement was done weekly using the Perkins hand held Tonometer. The third phase consisted of oculo hypertensive cat eyes (25.275 ± 0.363mmHg), which were further divided into control-1 and experimental group. The control-1 group (4 eyes) was left untreated, while the experimental group was divided into 2 groups, the mushroom treated (4 eyes) and timolol treated (4 eyes) for 15 days. Mushroom extract decreasel IOP below baseline level showing a significant (p < 0.001) IOP reduction of 5.24% better than the control group, while timolol was only 0.85% better.

Keywords
Mushroom extract, Timolol maleate, Dexamethasone and ocular hypertension.

 
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