Sir,
A 40-year-old man, weighing 81 kg, with no previous history of heart disease presented with complaint of fever since 25 days. Ultrasonography and computed tomography of abdomen showed altered echotexture and multiple splenic hypodense lesions. Aspiration and culture showed the growth of Candida tropicalis and a rising serological titre from 1:256 to 1:1024. The patient was started on intravenous amphotericin B 8 mg (0.1 mg/kg body weight) over three hours after a test dose of 1 mg. After a cumulative dose of 28 mg, he developed a life-threatening ventricular tachycardia which was DC-verted to normal sinus rhythm.
