Editorial - Antiphospholipid Syndrome and Recurrent Miscarriage

Recurrent miscarriage, the loss of three or more consecutive pregnancies affects 1% of couples trying to conceive. This is significantly higher than that expected by chance alone and implies that some couples have a persistent underlying abnormality to account for their pregnancy losses. Since its original description almost twenty years ago, the antiphospholipid syndrome (APS) has emerged as the most important treatable cause of recurrent miscarriage. The APS is also an important cause of early onset pre-eclampsia and of intra-uterine growth restriction (IUGR).¹